Jordan Raanan of ESPN.com indicated that Barkley was undergoing X-rays, with a final determination to be made on Monday.
“The New York Giants fear that running back Saquon Barkley tore the ACL in his right knee Sunday, sources told ESPN,” wrote Raanan.
“One source said a torn ACL was ‘certainly within the realm.'”
When Barkley left the field following the injury, he appeared to be in severe pain. That image and the likely diagnosis blow a huge hole in the Giants’ rebuilding efforts for 2020.
Barkley, the second overall pick in the 2018 NFL Draft, had come off consecutive 1,000-yard seasons and was looking to be the centerpiece of the Giants’ effort to bounce back from three straight miserable seasons.